Diving Deeper into Niacinamide - Multi Benefits

In this article let me introduce you to the superstar of vitamins - Niacinamide, or as it's fondly known in the vitamin world, Nicotinamide. Actually it is a form of vitamin B3, playing a crucial role in energy metabolism. Without it, your little mitochondria buddies can't whip up any energy for you. And who wants to walk around like a deflated balloon? Certainly not me! Niacinamide is not just a one-trick pony. It holds the key to NAD+, which is like the ultimate secret agent in the conversion of food to energy. It's the boss that maintains the integrity of your DNA and keeps your cells functioning smoothly. And guess what? This NAD+ is also the fuel for some longevity proteins that start running low as we age. So, if you want to hop on the anti-ageing train, Niacinamide is your golden ticket.

Recent research has uncovered a shocking truth. Our basic metabolic rate has been on a steady decline for over a century, and that alone can explain the massive obesity epidemic we're facing. It's like we're becoming professional couch potatoes, burning fewer calories even when we're just lounging around. Blame it on those horrible polyunsaturated fats we've been gobbling up. Those sneaky devils are single-handedly responsible for this decline in our metabolic prowess. Anyway, no need to get desperate as Niacinamide is here to save the day! Not only does it have some serious anti-obesity effects, but it also knows how to keep those mean inflammatory polyunsaturated fats in check. It's like a professional boxer fighting off the bad guys in your fat cells. And that's not all as this wonder vitamin can also prevent neurodegeneration, kidney disease, heart failure, and even reverse that gut of yours from leaking. Talk about a multitasking genius!

Now, brace yourselves for some bio-hacking wisdom from the one and only Georgi Dinkov. He's been spreading the gospel of Niacinamide and all its incredible benefits. From energy metabolism to the vital role it plays in the mitochondrial electron transport chain, this vitamin is like the MVP of vitality. Trust me when I say, your mitochondria will be dancing a little jig of joy with all that extra energy floating around. I'll let you in on a little secret to unleash the full power of Niacinamide. Just a daily dose of 50 milligrams will get NAMPT, the rate-limiting enzyme for NAD+, all fired up and ready to go. That's the magic number, my friends. Not only will it keep you looking fresh and youthful, but it also fights off obesity like a champion, protects your precious neurons, and keeps your ticker ticking happily. So, don't wait another second. Grab that bottle of Niacinamide and unlock the secrets of energy, longevity, and overall awesomeness. Your body will thank you, and who knows, maybe you'll become the next bio-hacking legend. Get ready to rule the world, one vitamin at a time!

Connection Between Declining Basic Metabolic Rate & the Obesity Epidemic

In a sizzling article from May 2023, the brilliant Dinkov dropped a bombshell on the obesity epidemic. It turns out that lack of exercise and stuffing our faces with goodies might not be the main culprits. Who would've thought? Now are you ready to delve into the wild world of basal metabolic rate (BMR)? It's like that nerdy cousin you see at a Christmas dinner who quietly burns calories while resting. Apparently, our BMR has been on a steady decline for a whole century. Yes, you read that right. Our bodies have become masters of laziness, burning fewer calories than our ancestors while lounging in our Snuggies. Some scientific researchers published a paper in April 2023, revealing that the BMR of our fine gentlemen has sunk by a whopping 14.7% since the 90s. The ladies didn't experience such a dramatic drop, but when they zoomed out and looked at data stretching back a hundred years, they found a significant decline for both sexes. It appears that our bodies have given up on their calorie-burning dreams.

According to Dinkov, it's not rocket science to realise that we're doomed in the BMR department. If we've had double-digit declines for three decades, we're probably only burning half the calories that our great-grandparents did. Goodnight, dreams of devouring donuts guilt-free. You know what makes this whole situation even juicier? It is these fancy guidelines that tell us to eat less and move more? Yeah, they're actually going to make things worse. In a world where BMR is taking a nosedive, reducing calories and sweating buckets won't save us. They'll just push our metabolism even further down the drain. Thanks, guidelines. We're stuck between a rock and a hard place, or rather, between a burger and a salad. Now, let's talk about the possible villain causing our BMR to shrink faster than a puddle in the sun. Aside from the perpetual stress we all love to hate, it seems that the decline in BMR matches up suspiciously well with our consumption of polyunsaturated fats (PUFA). As the BMR curve has plunged over the past century, the PUFA consumption rate has had a fantastic upward trajectory. Is it coincidence? I think not.

Dinkov predicts that unless we intervene and stop the ever-increasing PUFA consumption spree, our BMR decline will continue its downward spiral. Forget about flipping the script or hitting the reboot button on our metabolism. It's a one-way street to a sluggish existence. So, the plot thickens. It seems that exercise and calorie intake might not be the primary suspects in this mysterious obesity epidemic. Our BMR is playing its part in this grand drama, conspiring with PUFA consumption to keep us firmly planted on the couch. It's a bizarre world we live in!

Impact of Niacinamide on Obesity Reduction

In a recent jaw-dropping article, Dinkov spills the beans on some mind-blowing research that unveils the miraculous powers of Niacinamide. Brace yourselves, because this vitamin is about to rewrite the rules of cellular metabolism in adipose (a fancy term for fat) tissue. Prepare to witness mitochondrial biogenesis like never before! Get this - Niacinamide has the audacity to kick obesity-related metabolic dysfunction to the curb by flexing its muscles in the realm of fatty acid catabolism. Talk about taking names and shedding pounds! In a daring experiment, our chubby mouse comrades were treated to a daily dose of 2.5 mg of Niacinamide per kilo of bodyweight for a mere three weeks. And boy! Did those mice deliver!

Not only did these mice bid farewell to a whopping 47% of their body fat, but hold on to your seats because this feat was achieved regardless of whether they stuffed their faces with a regular diet or a high-fat bonanza. Talk about breaking stereotypes! But wait, there's more - lean muscle mass skyrocketed, mitochondria multiplied like bunnies, and energy production went through the roof. These mice partied so hard that their CO2 levels shot up, and their physical activity levels were off the charts! But wait, there's a cherry on top. Insulin sensitivity gets a massive boost courtesy of our potent B vitamin, Niacinamide. It's like a rags-to-riches Cinderella transformation for these obese mice. Who needs a fairy godmother when you have a magical vitamin? I’m convinced that Niacinamide is about to prove that it's the holy grail of fat loss. It's time for those extra pounds to shake in their boots and say their goodbyes. Niacinamide is here to save the day, one adipose cell at a time!

Beneficial Role of Niacinamide in Eliminating PUFAs

Let's investigate the world of Niacinamide and its role in the grand scheme of things. Brace yourself for some fascinating insights! See, Niacinamide has a party trick up its sleeve - it raises NAD+. And what does NAD+ do? Well, it acts like a bouncer at a club and stops the release of inflammatory polyunsaturated fats (PUFAs) from your fat cells. Talk about being anti-lipolytic, it's like having a bodyguard protecting your body! Now, why is that a good thing? When these PUFAs, like linoleic acid (LA), are set free from your fat cells, they morph into highly inflammatory molecules. Think of it as unleashing a wildfire and you certainly want to control that burn. These PUFAs, unlike saturated fats, prefer to hang around and get stored in your body, embedding themselves into the cell membranes for a mind-boggling 680-day half-life. To get rid of LA, you'd have to wait for approximately seven years, unless you keep shovelling more of it in. Seems like PUFAs are playing the long game, huh? Now, here's the interesting part. Turns out, most of the body fat in obese individuals is made up of these sneaky PUFAs. They're like the uninvited guests at a party, wreaking havoc in your system. To keep things under control, you want to reduce these stored PUFAs to safe levels of 1% to 2% LA. That should be the goal here.

But hang on, there's even more! Alongside Niacinamide, we have aspirin joining the anti-lipolytic squad, also making sure the LA release from your fat cells happens at a snail's pace. Looks like double trouble, right? And let's not forget our good old friend, vitamin E. This amazing buddy does it all! Not only does it prevent LA from converting into those dangerous oxidative linoleic acid metabolites (OXLAMs) once released, but it also puts up a barrier against LA's mischievous ways. Talk about multitasking! Now, here's some advice for you. Don't fall for those bogus vitamin E supplements. You have to be picky! Look for the ones with alpha tocopherol as the main player. Aim for around 150 units, and make sure it includes those other tocopherol isomers - alpha, beta, and gamma - but in lower doses. Throw in some alpha, beta, and gamma tocotrienols for good measure. And hey, just stick with the "D" isomer, leave the "DL" ones behind. I’m sure, it's the cool kid of the vitamin E gang. So, there you have it. Niacinamide, aspirin, and high-quality vitamin E makes an epic team fighting the battle against inflammatory fats. Let's keep those PUFAs at bay and give your body a well-deserved break from their chaos!

Neuroprotective Effects of Niacinamide Explored

In an article from May 2023, Dinkov dives into the fascinating world of Niacinamide and its potential to prevent our brains from turning into mush. Apparently, this little compound can give our energy levels a mighty boost by tinkering with those mitochondria thingamajigs responsible for energy metabolism. It turns out that a drop in NAD+ levels, the fancy acronym for a molecule that plays a crucial role in our brain health, is a common characteristic of most neurodegenerative diseases. So, by raising NAD+ levels, we may just save ourselves from the clutches of Alzheimer's or a pesky ischemic stroke. Dinkov doesn't stop there. He also mentioned a study that claims autophagy, which is like a janitorial service for our brains, plays a pivotal role in maintaining optimal NAD+ levels. When autophagy is slacking off, our brain cells suffer, resulting in some serious brain tissue degeneration.

However, Dinkov has a solution up his sleeve. He suggests boosting NAD+ levels by using Niacinamide, along with a bunch of other fancy precursors like nicotinamide mononucleotide, nicotinamide riboside, or Niacin, which apparently also goes by the name vitamin B3. However, after deep contemplation, Dinkov decides that Niacinamide is the bee's knees, the crème de la crème of NAD+ boosters. Why doesn't everyone’s grandma talk about it, you may wonder? Well, apparently, it's just too darn inexpensive to generate any financial incentives. Who would have thought, right? Dinkov throws in another affordable option to ramp up autophagy – the good old aspirin. Yes, the humble aspirin, known for its headache-relieving powers, may also activate autophagy without the annoying side effect of sending our cortisol levels into overdrive. Georgi chimes in by suggesting that since aspirin is a great autophagy modulator and Niacinamide is a top-notch NAD+ producer, combining them should create a synergistic brain-protecting powerhouse. So, if you want to keep your brain in tiptop shape, maybe it's time to stock up on aspirin and Niacinamide. Who knew the secret to a healthy brain could be found on the shelves of your local pharmacy?

But hold on tight, because Dinkov isn't finished yet dropping knowledge bombs. He reveals that this study dares to challenge the almighty sirtuins, those trendy anti-ageing targets everyone has been raving about. Turns out, these sirtuin genes are major NAD consumers and actually get more active as we age. They are sneaky little buggers. No worries, for Dinkov delivers some sweet relief: Niacinamide not only boosts NAD+ but also has the power to inhibit those greedy NAD-consuming enzymes. Take that, sirtuins! No other NAD precursors have shown this inhibiting prowess so far, so Niacinamide takes the crown as the ultimate brain protector and enzyme slayer. In conclusion, Niacinamide is the unsung hero of the brain health world, standing tall against neurodegeneration and giving a big fat middle finger to those NAD-sucking sirtuins. So, go forth and raise those NAD+ levels, armed with the power of Niacinamide and a trusty bottle of aspirin by your side. Keep those brain cells happy, healthy, and ready to take on the world.

Why You Should Choose Niacinamide?

Ok, all you NAD+ enthusiasts, because we’ve uncovered the secret behind the best NAD+ precursor. Brace yourselves for some science. You see, the magical thing about Niacinamide is that it's like the immediate BFF of NAD+. When NAD+ gets used up, it breaks down into Niacinamide. It's a beautiful cycle, really. Now, some smarty-pants researchers out there are hyping up NMN. They claim it's all cool because it turns into NAD+ after being converted from Niacinamide. Well, guess what? The enzyme NMNAT1-3, responsible for that conversion, isn’t the big boss here. No, no, no. It's our buddy NAMPT that calls the shots on NAD+ production.

So, here's the deal. Instead of bombarding your precious body with a bunch of NMN, it is way more effective to go with small doses of Niacinamide and kick NAMPT into high gear. Trust me on this. We've got the ideal Niacinamide dosage right here: 50 mg three times a day. It's a simple intervention that can do wonders for boosting your NAD+ levels. And let me tell you, those who don't respond positively to this marvellous approach are few and far between. So, jump on the Niacinamide train and embrace the power of NAMPT activation. Your body will thank you, and you'll be riding the NAD+ wave like a champion.

Preventing Kidney Disease with Niacinamide

In the fantastical realm of NAD+, it turns out that running low on this fancy-sounding compound can lead to kidney disease. Thankfully, Niacinamide can help to prevent this! As explained by the illustrious Dinkov in an article dated May 18, 2023, various studies have uncovered the dastardly connection between lipolysis (which brings inflammatory PUFA to the kidneys) and the reviled Randle Cycle, which elevates fatty acid oxidation (FAO). And guess what? FAO has a penchant for shrinking the mitochondrial NAD/NADH ratio - essentially creating a NAD+ scarcity. This devious act of elevated FAO also puts a damper on glucose oxidation, as it hinders an enzyme known as pyruvate dehydrogenase, all in the name of chaos.

But hold on to your lab goggles! The study in question found that this NAD+ shortage is the main villain responsible for kidney damage, thanks to the ensuing OXPHOS dysfunction. However, there is a glimmer of hope. By boosting NAD+ levels (and the glorious NAD/NADH ratio) using precursors such as Nicotinamide mononucleotide (NMN) or Nicotinamide riboside (NR), the researchers were able to prevent kidney damage and CKD with a flourish. Sadly, NMN is no longer available for all to partake in, and NR seems to have a steep price tag. Fear not, for Niacinamide strides onto the scene, our trusty alternative option for us humble humans with CKD. Not only is Niacinamide just as capable as NMN/NR in being an NAD+ precursor, but it also possesses secret powers that its counterparts lack. Niacinamide possesses the amazing ability to inhibit the nefarious NAD-consuming enzymes PARP-1 and CD38. In simple language, by taking Niacinamide, we not only boost NAD+ levels but also stop them from being rapidly depleted.

Now, I must admit that I have tirelessly scoured the land for the actual published study this article is based on, but alas, it has eluded me thus far. Nevertheless, other studies have shown promising results for CKD in our furry friends, with human-equivalent (HED) doses falling into the 250mg-500mg daily range. So, let us embark on this NAD+-enhancing journey with Niacinamide as our trusty sidekick, and conquer kidney disease one day at a time!

Niacinamide for Leaky Gut

Niacinamide, the miracle worker, comes to save the day for all you leaky guts out there. You see, when nasty toxins like lipopolysaccharide decide to escape your gut and wreak havoc in your bloodstream, they cause inflammation that fuels all sorts of chronic diseases. But don’t worry! Recent research suggests that leaky gut may actually stem from an energy deficiency, and guess who can fix that? Yep, it's our good old friend Niacinamide! According to the scientists, our intestinal epithelial cells (the fancy cells that make up the gut barrier) use up a whopping 20% of the ATP we produce daily. So, when our ATP levels take a nosedive, these cells start malfunctioning like a broken down car. And what's to blame for this energy shortage? Well, those vicious gram-negative members of our microbiome, producing their favourite toxin, endotoxin (LPS). It's like a big bad wolf blowing down the house of our gut barrier.

But don't despair, because here comes Niacinamide, riding in on its white horse of healing. In a super cool study, they used ethanol (a major ATP depleting agent) to mess with the energy levels of those epithelial cells, and surprise, surprise, endotoxin levels skyrocketed. But, lo and behold, when they gave those cells a dose of Niacinamide (at a human-equivalent dose of 30mg/kg daily for 10 days), it was like a superhero swooping in to save the day. The Niacinamide not only prevented endotoxemia, but it also fixed all the energy deficits, restoring order to the gut barrier. It even went above and beyond by surpassing the energy levels of the healthy control group. Talk about an overachiever! Now, before you start thinking, "But I'm not a heavy drinker, so this doesn't apply to me," hold your horses, my friend. Even the endotoxin naturally produced in our intestines when we chow down on some grub can lead to the same energy depletion in those intestinal cells, resulting in a leaky gut situation. That’s sneaky, huh? But luckily, Niacinamide's got your back.

Now, let's address the dose. Yes, 30mg may seem like a lot, but hey, it's still below the toxic threshold, so no need to panic. And don't forget, the study only lasted 10 days because they were using ethanol for the same duration. So, if you're not hitting the bottle every day, you likely won't need Niacinamide daily either. A sensible approach would be to take that 30mgon weekends (just 2 days) or maybe twice a month as a general gut-repair routine. But if you fancy a daily dose, somewhere between 200mg-300mg should do the trick! At Ancient Purity, we recommend a dose of 50mg three times daily. And here's an interesting tidbit for you: other studies have shown that a daily dose of 300mg Niacinamide can boost your NAD levels just as effectively as 1,000mg. So, you can still achieve those awesome benefits with a smaller daily dose. So, there you have it, folks! Niacinamide, your gut's saviour, ready to repair, restore, and kick leaky gut's butt. Give it a whirl and let the healing begin!

Preventing Heart Failure with Niacinamide

And there’s the never-ending quest to keep our hearts ticking like a Swiss watch. Well, Niacinamide swoops in as a potential hero. Turns out, this mighty compound may have the power to ward off heart failure. How, you ask? Well, let me break it down for you in the most brilliant and witty way possible. You see, heart failure is like a red flag waving frantically in the face of energy deficiency and mitochondrial dysfunction. It's like your heart throwing a tantrum because it's running on empty. And that's where Niacinamide steps in, armed with its cape made of prevention. When your NAD+ (Nicotinamide adenine dinucleotide) level decides to take a nosedive, your ATP (adenosine triphosphate) level also takes a plunge. And guess what? That puts some serious stress on the cardiomyocytes - those specialised cells responsible for generating the love beats in our hearts. Imagine the poor cardiomyocytes going, "Hey, heart, we're doing our best here, but we can't work miracles on an empty tank!" So, to express their frustration, they release pro-fibrotic mediators, which are essentially like sending an eviction notice to your mitochondria, the powerhouses of your cells.

This tragic dance of stress and suppression ultimately leads to a sad symphony of heart failure hallmarks - cell death, collagen deposits, and fibrosis. But research conducted in February 2023 has shown that replenishing NAD+ can put an end to this energetic dysfunction and save our hearts from doom. Now, before you start envisioning yourself getting jabs with a needle every day, hold your horses! In this study, they played the guinea pig game with our human-equivalent pals by administering 3.5 mg per kilo of bodyweight through daily injections for two months. But hey, both Dinkov and I have a sneaky suspicion that perhaps good old oral Niacinamide might work just as well. It might take a tad longer, but hey, Rome wasn't built in a day either. So, take note! Niacinamide could be the secret weapon to keep your ticker in tip-top shape. Just make sure to stock up on this energetic saviour, whether it's in injection form or through the power of oral consumption. Keep those cardiomyocytes happy, and your heart will sing like a diva. Cheers to beating hearts and preventing heartache!

General Niacinamide Recommendations

What’s the recommended intake for optimal health? Well, have I got the recommendation for you! Picture this: three times a day, pop 50 mg of Niacinamide like it's nobody's business. And guess what? It won't even dent your piggy bank! For a mere 25 cents a month, you can nab yourself some powdered Niacinamide or a 50mg tablet. Just a smidge – about one-sixty-fourth of a teaspoon – will do the trick. Now, here's the deal with this powdered wonder: it's essential to nab it in its pure form 'cause most supplement brands only offer doses as high as 500 mg. But who needs all that excess? It'll mess with the NAD+ levels and dunk on NAMPT, and that's the opposite of what you're shooting for. Trust me! You want the good stuff - Niacinamide. Don't be fooled by its cousin Niacin, which may go by the same B3 name but won't activate NAMPT like Niacinamide does. Stick with what works!

Oh, and a little bonus: with Niacinamide, you won't have to worry about that disturbing flushing sensation, courtesy of histamine overload. Leave that drama behind! While we're at it, let's not forget our buddies, the other B vitamins. They're crucial for mitochondrial function, too. Regular niacin, riboflavin, and folate are your team players. If you find your mitochondrial mojo is a bit off, it's probably due to a B vitamin deficiency. Lucky for you, it's an easy fix with a nifty, low-dose, high-quality B complex. Give it two to three weeks tops and you'll see the improvement you've been missing all along. So there you have it, all health aficionados. Grab your Niacinamide, stock up on those B vitamins, and watch your wellness soar to new heights. Your mitochondria will thank you, and you'll be strutting your healthy self in no time! You can order Ancient Purity Niacinamide (Vitamin B3) Here!

''If forgiveness is medicine for the soul, then gratitude is vitamins.'' - Steve Maraboli